Antioxidant enzyme deficiencies and vascular disease

Vitamin deficiencies in chronic kidney disease

Peroxisomal disorders: the single peroxisomal enzyme deficiencies.

Peroxisomal disorders are a group of inherited diseases in man in which either peroxisome biogenesis or one or more peroxisomal functions are impaired. The peroxisomal disorders identified to date are usually classified in two groups including: (1) the disorders of peroxisome biogenesis, and (2) the single peroxisomal enzyme deficiencies. This review is focused on the second group of disorders,...

Modulation of oxidant and antioxidant enzyme expression and function in vascular cells.

Pathological conditions that predispose to cardiovascular events, such as hypertension, hypercholesterolemia, and diabetes, are associated with oxidative stress. These observations and further data derived from a plethora of investigations provided accumulating evidence that oxidative stress is decisively involved in the pathogenesis of endothelial dysfunction and atherosclerosis. Several enzym...

Targeting Cellular Antioxidant Enzymes for Treating Atherosclerotic Vascular Disease

Atherosclerotic vascular dysfunction is a chronic inflammatory process that spreads from the fatty streak and foam cells through lesion progression. Therefore, its early diagnosis and prevention is unfeasible. Reactive oxygen species (ROS) play important roles in the pathogenesis of atherosclerotic vascular disease. Intracellular redox status is tightly regulated by oxidant and antioxidant syst...

Antioxidant Enzyme Activities and Antioxidant Enzyme Gene Expression in Hyperoxia-induced Lung Injury in Premature Rat

Preterm infants exposed to high concentration oxygen are prone to develop hyperoxic lung damage, which is an importan t underly ing cause of bronchopulmonary dysplasia (BPD).1 Although the causative agent for BPD has not been conclusively identified, hyperoxia-induced lung injury i s bel ieved to be a major factor. Data from both cellu lar and whole animal models suggest that hyperoxic lung dam...